It’s been a busy spring here in the Stupack Lab. We’ve been coalescing several manuscripts for publication, and we are proud to announce that we now have a few additions to our publication list:
Graf R, Keller N, Barbero S, Stupack DG. Caspase-8 as a Regulator of Tumor Cell Motility. Current Molecular Medicine. (In Press)
Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, et al. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adhesion & Migration. 2013 Jun 10;7(4). PubMed PMID: 23751956. Epub 2013/06/12.
Shanique A. Young, Ryon Graf and Dwayne G. Stupack (2013). Neuroblastoma Integrins, Neuroblastoma, Prof. Hiroyuki Shimada (Ed.), ISBN: 978-953-51-1128-3, InTech, DOI: 10.5772/55991. Available from: http://www.intechopen.com/books/neuroblastoma/neuroblastoma-integrins
“Caspase-8 as a Regulator of Tumor Cell Motility” has been accepted to Current Molecular Medicine and is a review article on the molecular mechanisms of how caspase-8 can promote cellular migration, a process central to tumor metastasis, independent of its better-defined role as a cell death protein.
“Src Inducible Association of CrkL with Procaspase-8 Promotes Cell Migration” has been accepted to Cell Adhesion and Migration and is available here. In this study, we expand upon a mechanism by which Caspase-8 (“Procaspase-8″ indicates the immature non-activated version of the protein) can promote cellular migration, identifying a new interacting protein (CrkL) and the modifying enzyme (Src) that facilitates this interaction.
The book chapter: “Neuroblastoma Integrins” is currently available via open access: http://www.intechopen.com/books/neuroblastoma/neuroblastoma-integrins We reviewed and consolidated information about the role of integrins (cell adhesion molecules critical to development, cell migration, and other roles) in neuroblastoma, the most common pediatric solid cancer. We also expand upon current concepts of therapy, and suggest new avenues for investigation by clinical pediatric oncologists.