Three New Publications!

It’s been a busy spring here in the Stupack Lab.  We’ve been coalescing several manuscripts for publication, and we are proud to announce that we now have a few additions to our publication list:

Graf R, Keller N, Barbero S, Stupack DG. Caspase-8 as a Regulator of Tumor Cell Motility. Current Molecular Medicine. (In Press)

Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, et al. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adhesion & Migration. 2013 Jun 10;7(4). PubMed PMID: 23751956. Epub 2013/06/12.

Shanique A. Young, Ryon Graf and Dwayne G. Stupack (2013). Neuroblastoma Integrins, Neuroblastoma, Prof. Hiroyuki Shimada (Ed.), ISBN: 978-953-51-1128-3, InTech, DOI: 10.5772/55991. Available from:

“Caspase-8 as a Regulator of Tumor Cell Motility” has been accepted to Current Molecular Medicine and is a review article on the molecular mechanisms of how caspase-8 can promote cellular migration, a process central to tumor metastasis, independent of its better-defined role as a cell death protein.

“Src Inducible Association of CrkL with Procaspase-8 Promotes Cell Migration” has been accepted to Cell Adhesion and Migration and is available here. In this study, we expand upon a mechanism by which Caspase-8 (“Procaspase-8″ indicates the immature non-activated version of the protein) can promote cellular migration, identifying a new interacting protein (CrkL) and the modifying enzyme (Src) that facilitates this interaction.

The book chapter: “Neuroblastoma Integrins” is currently available via open access: We reviewed and consolidated information about the role of integrins (cell adhesion molecules critical to development, cell migration, and other roles) in neuroblastoma, the most common pediatric solid cancer. We also expand upon current concepts of therapy, and suggest new avenues for investigation by clinical pediatric oncologists.

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Our graduate students at the ASMB – SFG conference

16 November 2012

This last week our two graduate students Shanique Young and Ryon Graf presented posters of their research at a major international scientific conference held right in their own backyard: downtown San Diego. To the backdrop of the beautiful white-sailboat-filled San Diego Bay, the Sheraton Hotel hosted scientists from as far away as Israel and Finland as they converged upon the joint symposium of the American Society of Matrix Biology and the Society for Glycobiology.

Image: Ryon poses with his research poster.

Shanique presented her new research on the roles of integrins in models of neuroblastoma metastasis, and Ryon presented on conditional protein interactions that might link together therapeutically relevant areas of cancer biology.

Both students received great feedback on their work, and enjoyed the open, collaborative environment. Although science is communicated more and more electronically in the 21st century, there are many positive benefits to the more socially inclined research conferences such as these, like forging future collaborations.

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Busy Summer

Summer might be winding down, but things are busy here in the Stupack Lab. Our scientists are currently performing experiments with: purified protein, cancer cells, cancer stem cells, cancer cells in extracellular matrix and mock-cancer environments, with mice, and slowly coalescing data, ideas, insights, and models into several manuscripts that are being prepared as this is typed.

Happy Summer!

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Quote of the day

The absolute worst ideas are the ones people keep to themselves.

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Happy Pi day!

Today is 3.14 (year 2012). Happy Pi day to all the math and science fans out there.

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How to properly water a pet cactus

Everything in a medical research laboratory must be properly cared for and maintained. Here is Ryon demonstrating proper cactus watering technique, complete with carefully measured water volume, protective clothing and eyewear. It’s much better than pouring water on the poor cactus’s head or trying to lift him out of his pot.

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A little science humor:

Most information in biology follows the path: DNA -> RNA -> Protein. But, certain viruses can also do RNA -> DNA. So, they were named “retro” viruses. Their information literally “goes back” into the host genome to complete its life cycle.

image source:

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